User profiles for "author:Alexandra Freeman"

Alexandra LJ Freeman

University of Cambridge
Verified email at cam.ac.uk
Cited by 4936

Communicating uncertainty about facts, numbers and science

AM Van Der Bles, S Van Der Linden… - Royal Society …, 2019 - royalsocietypublishing.org
Uncertainty is an inherent part of knowledge, and yet in an era of contested expertise, many
shy away from openly communicating their uncertainty about what they know, fearful of their …

DOCK8 deficiency: clinical and immunological phenotype and treatment options-a review of 136 patients

SE Aydin, SS Kilic, C Aytekin, A Kumar… - Journal of clinical …, 2015 - Springer
Mutations in DOCK8 result in autosomal recessive Hyper-IgE syndrome with combined
immunodeficiency (CID). However, the natural course of disease, long-term prognosis, and …

The hyper-IgE syndromes

AF Freeman, SM Holland - Immunology and allergy clinics of North …, 2008 - Elsevier
The hyper-IgE syndromes (HIES) are rare primary immune deficiencies characterized by
elevated serum IgE, rash, and recurrent bacterial infections of the skin and lung. Autosomal …

Risk perceptions of COVID-19 around the world

S Dryhurst, CR Schneider, J Kerr, ALJ Freeman… - COVID …, 2022 - taylorfrancis.com
The World Health Organization has declared the rapid spread of COVID-19 around the
world a global public health emergency. It is well-known that the spread of the disease is …

[HTML][HTML] STAT3 Mutations in the Hyper-IgE Syndrome

SM Holland, FR DeLeo, HZ Elloumi… - … England Journal of …, 2007 - Mass Medical Soc
Background The hyper-IgE syndrome (or Job's syndrome) is a rare disorder of immunity and
connective tissue characterized by dermatitis, boils, cyst-forming pneumonias, elevated …

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

JD Milner, JM Brenchley, A Laurence, AF Freeman… - Nature, 2008 - nature.com
The autosomal dominant hyper-IgE syndrome (HIES,'Job's syndrome') is characterized by
recurrent and often severe pulmonary infections, pneumatoceles, eczema, staphylococcal …

Susceptibility to misinformation about COVID-19 around the world

J Roozenbeek, CR Schneider… - Royal Society …, 2020 - royalsocietypublishing.org
Misinformation about COVID-19 is a major threat to public health. Using five national
samples from the UK (n= 1050 and n= 1150), Ireland (n= 700), the USA (n= 700), Spain (n …

[HTML][HTML] Combined Immunodeficiency Associated with DOCK8 Mutations

Q Zhang, JC Davis, IT Lamborn… - … England Journal of …, 2009 - Mass Medical Soc
Background Recurrent sinopulmonary and cutaneous viral infections with elevated serum
levels of IgE are features of some variants of combined immunodeficiency. The genetic …

GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity

MA Spinner, LA Sanchez, AP Hsu… - Blood, The Journal …, 2014 - ashpublications.org
Haploinsufficiency of the hematopoietic transcription factor GATA2 underlies monocytopenia
and mycobacterial infections; dendritic cell, monocyte, B, and natural killer (NK) lymphoid …

Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome

AP Hsu, EP Sampaio, J Khan, KR Calvo… - Blood, The Journal …, 2011 - ashpublications.org
The syndrome of monocytopenia, B-cell and NK-cell lymphopenia, and mycobacterial,
fungal, and viral infections is associated with myelodysplasia, cytogenetic abnormalities …