[HTML][HTML] A multipotent progenitor domain guides pancreatic organogenesis

Q Zhou, AC Law, J Rajagopal, WJ Anderson, PA Gray… - Developmental cell, 2007 - cell.com
The mammalian pancreas is constructed during embryogenesis by multipotent progenitors,
the identity and function of which remain poorly understood. We performed genome-wide …

β-catenin is essential for pancreatic acinar but not islet development

LC Murtaugh, AC Law, Y Dor, DA Melton - 2005 - journals.biologists.com
Despite our increasingly sophisticated understanding of transcriptional regulation in
pancreas development, we know relatively little about the extrinsic signaling pathways …

Comparative effectiveness of fludrocortisone and hydrocortisone vs hydrocortisone alone among patients with septic shock

NA Bosch, B Teja, AC Law, B Pang… - JAMA Internal …, 2023 - jamanetwork.com
Importance Patients with septic shock may benefit from the initiation of corticosteroids.
However, the comparative effectiveness of the 2 most studied corticosteroid regimens …

Lottery-based incentives and COVID-19 vaccination rates in the US

AC Law, D Peterson, AJ Walkey… - JAMA internal …, 2022 - jamanetwork.com
Methods| We identified lottery states that announced cash prizes for vaccinated individuals
from May 24, 2021, to July 19, 2021. States that announced lotteries outside of this period …

Predictive validity of the sequential organ failure assessment score versus claims-based scores among critically ill patients

NA Bosch, AC Law, JM Rucci, D Peterson… - Annals of the …, 2022 - atsjournals.org
Methods We used the Premier, Inc. multicenter database (8)(2016–2020) to identify adult
patients admitted to intensive care units on Day 1 of admission. For each patient, we …

Effectiveness of Fludrocortisone Plus Hydrocortisone Versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized …

B Teja, M Berube, TV Pereira, AC Law… - American Journal of …, 2024 - atsjournals.org
Rationale: The use of hydrocortisone in adult septic shock is controversial, and effectiveness
of adding fludrocortisone to hydrocortisone remains uncertain. Objective: To assess …

Comparison of propylthiouracil vs methimazole for thyroid storm in critically ill patients

SY Lee, KL Modzelewski, AC Law, AJ Walkey… - JAMA Network …, 2023 - jamanetwork.com
Importance Thyroid storm is the most severe form of thyrotoxicosis, with high mortality, and is
treated with propylthiouracil and methimazole. Some guidelines recommend propylthiouracil …

Patient outcomes after the introduction of statewide ICU nurse staffing regulations

AC Law, JP Stevens, S Hohmann… - Critical Care …, 2018 - journals.lww.com
Objectives: To assess whether Massachusetts legislation directed at ICU nurse staffing was
associated with improvements in patient outcomes. Design: Retrospective cohort study; …

Patient Outcomes After Long-Term Acute Care Hospital Closures

AC Law, NA Bosch, Y Song, A Tale, RW Yeh… - JAMA Network …, 2023 - jamanetwork.com
Importance Long-term acute care hospitals (LTCHs) are common sites of postacute care for
patients recovering from severe respiratory failure requiring mechanical ventilation (MV) …

Gastrostomy tube use in the critically ill, 1994–2014

AC Law, JP Stevens, AJ Walkey - Annals of the American Thoracic …, 2019 - atsjournals.org
Rationale: Although gastrostomy tubes have shown to be of limited benefit in patients with
advanced dementia, they continue to be used to deliver nutritional support in critically ill …