[HTML][HTML] A multipotent progenitor domain guides pancreatic organogenesis
The mammalian pancreas is constructed during embryogenesis by multipotent progenitors,
the identity and function of which remain poorly understood. We performed genome-wide …
the identity and function of which remain poorly understood. We performed genome-wide …
β-catenin is essential for pancreatic acinar but not islet development
Despite our increasingly sophisticated understanding of transcriptional regulation in
pancreas development, we know relatively little about the extrinsic signaling pathways …
pancreas development, we know relatively little about the extrinsic signaling pathways …
Comparative effectiveness of fludrocortisone and hydrocortisone vs hydrocortisone alone among patients with septic shock
Importance Patients with septic shock may benefit from the initiation of corticosteroids.
However, the comparative effectiveness of the 2 most studied corticosteroid regimens …
However, the comparative effectiveness of the 2 most studied corticosteroid regimens …
Lottery-based incentives and COVID-19 vaccination rates in the US
Methods| We identified lottery states that announced cash prizes for vaccinated individuals
from May 24, 2021, to July 19, 2021. States that announced lotteries outside of this period …
from May 24, 2021, to July 19, 2021. States that announced lotteries outside of this period …
Predictive validity of the sequential organ failure assessment score versus claims-based scores among critically ill patients
Methods We used the Premier, Inc. multicenter database (8)(2016–2020) to identify adult
patients admitted to intensive care units on Day 1 of admission. For each patient, we …
patients admitted to intensive care units on Day 1 of admission. For each patient, we …
Effectiveness of Fludrocortisone Plus Hydrocortisone Versus Hydrocortisone Alone in Septic Shock: A Systematic Review and Network Meta-Analysis of Randomized …
Rationale: The use of hydrocortisone in adult septic shock is controversial, and effectiveness
of adding fludrocortisone to hydrocortisone remains uncertain. Objective: To assess …
of adding fludrocortisone to hydrocortisone remains uncertain. Objective: To assess …
Comparison of propylthiouracil vs methimazole for thyroid storm in critically ill patients
Importance Thyroid storm is the most severe form of thyrotoxicosis, with high mortality, and is
treated with propylthiouracil and methimazole. Some guidelines recommend propylthiouracil …
treated with propylthiouracil and methimazole. Some guidelines recommend propylthiouracil …
Patient outcomes after the introduction of statewide ICU nurse staffing regulations
AC Law, JP Stevens, S Hohmann… - Critical Care …, 2018 - journals.lww.com
Objectives: To assess whether Massachusetts legislation directed at ICU nurse staffing was
associated with improvements in patient outcomes. Design: Retrospective cohort study; …
associated with improvements in patient outcomes. Design: Retrospective cohort study; …
Patient Outcomes After Long-Term Acute Care Hospital Closures
Importance Long-term acute care hospitals (LTCHs) are common sites of postacute care for
patients recovering from severe respiratory failure requiring mechanical ventilation (MV) …
patients recovering from severe respiratory failure requiring mechanical ventilation (MV) …
Gastrostomy tube use in the critically ill, 1994–2014
Rationale: Although gastrostomy tubes have shown to be of limited benefit in patients with
advanced dementia, they continue to be used to deliver nutritional support in critically ill …
advanced dementia, they continue to be used to deliver nutritional support in critically ill …