User profiles for "author:David Robert Grimes"
David Robert GrimesTrinity College Dublin Verified email at tcd.ie Cited by 2090 |
Methods: using three-dimensional culture (spheroids) as an in vitro model of tumour hypoxia
Regions of hypoxia in tumours can be modelled in vitro in 2D cell cultures with a hypoxic
chamber or incubator in which oxygen levels can be regulated. Although this system is …
chamber or incubator in which oxygen levels can be regulated. Although this system is …
Hypoxia imaging and radiotherapy: bridging the resolution gap
DR Grimes, DR Warren, S Warren - The British journal of …, 2017 - academic.oup.com
Oxygen distribution is a major determinant of treatment success in radiotherapy, with well-
oxygenated tumour regions responding by up to a factor of three relative to anoxic volumes …
oxygenated tumour regions responding by up to a factor of three relative to anoxic volumes …
Proposed mechanisms for homeopathy are physically impossible
DR Grimes - Focus on Alternative and Complementary …, 2012 - Wiley Online Library
Background Homeopathy is a system of complementary and alternative medicine based on
a belief that a malady can be treated by the administration of an extreme dilution of an agent …
a belief that a malady can be treated by the administration of an extreme dilution of an agent …
A method for estimating the oxygen consumption rate in multicellular tumour spheroids
Hypoxia occurs when oxygen levels within a tissue drop below normal physiological levels.
In tumours, hypoxia is associated with poor prognosis, increased likelihood of metastasis …
In tumours, hypoxia is associated with poor prognosis, increased likelihood of metastasis …
[HTML][HTML] Medical disinformation and the unviable nature of COVID-19 conspiracy theories
DR Grimes - PLoS One, 2021 - journals.plos.org
The coronavirus pandemic has seen a marked rise in medical disinformation across social
media. A variety of claims have garnered considerable traction, including the assertion that …
media. A variety of claims have garnered considerable traction, including the assertion that …
Modelling science trustworthiness under publish or perish pressure
Scientific publication is immensely important to the scientific endeavour. There is, however,
concern that rewarding scientists chiefly on publication creates a perverse incentive …
concern that rewarding scientists chiefly on publication creates a perverse incentive …
A mechanistic investigation of the oxygen fixation hypothesis and oxygen enhancement ratio
DR Grimes, M Partridge - Biomedical physics & engineering …, 2015 - iopscience.iop.org
The presence of oxygen in tumours has substantial impact on treatment outcome; relative to
anoxic regions, well-oxygenated cells respond better to radiotherapy by a factor 2.5–3. This …
anoxic regions, well-oxygenated cells respond better to radiotherapy by a factor 2.5–3. This …
[HTML][HTML] On the viability of conspiratorial beliefs
DR Grimes - PloS one, 2016 - journals.plos.org
Conspiratorial ideation is the tendency of individuals to believe that events and power
relations are secretly manipulated by certain clandestine groups and organisations. Many of …
relations are secretly manipulated by certain clandestine groups and organisations. Many of …
Health disinformation & social media: The crucial role of information hygiene in mitigating conspiracy theory and infodemics
DR Grimes - EMBO reports, 2020 - embopress.org
The satirist Johnathan Swift once lamented that “falsehood flies, and truth comes limping
after it”. Penned three centuries ago, these words seem alarmingly prescient: The paradox of …
after it”. Penned three centuries ago, these words seem alarmingly prescient: The paradox of …
Oxygen consumption dynamics in steady-state tumour models
DR Grimes, AG Fletcher… - Royal Society open …, 2014 - royalsocietypublishing.org
Oxygen levels in cancerous tissue can have a significant effect on treatment response:
hypoxic tissue is both more radioresistant and more chemoresistant than well-oxygenated …
hypoxic tissue is both more radioresistant and more chemoresistant than well-oxygenated …