User profiles for "author:David Robert Grimes"

David Robert Grimes

Trinity College Dublin
Verified email at tcd.ie
Cited by 2090

Methods: using three-dimensional culture (spheroids) as an in vitro model of tumour hypoxia

R Leek, DR Grimes, AL Harris, A McIntyre - Tumor Microenvironment …, 2016 - Springer
Regions of hypoxia in tumours can be modelled in vitro in 2D cell cultures with a hypoxic
chamber or incubator in which oxygen levels can be regulated. Although this system is …

Hypoxia imaging and radiotherapy: bridging the resolution gap

DR Grimes, DR Warren, S Warren - The British journal of …, 2017 - academic.oup.com
Oxygen distribution is a major determinant of treatment success in radiotherapy, with well-
oxygenated tumour regions responding by up to a factor of three relative to anoxic volumes …

Proposed mechanisms for homeopathy are physically impossible

DR Grimes - Focus on Alternative and Complementary …, 2012 - Wiley Online Library
Background Homeopathy is a system of complementary and alternative medicine based on
a belief that a malady can be treated by the administration of an extreme dilution of an agent …

A method for estimating the oxygen consumption rate in multicellular tumour spheroids

DR Grimes, C Kelly, K Bloch… - Journal of The Royal …, 2014 - royalsocietypublishing.org
Hypoxia occurs when oxygen levels within a tissue drop below normal physiological levels.
In tumours, hypoxia is associated with poor prognosis, increased likelihood of metastasis …

[HTML][HTML] Medical disinformation and the unviable nature of COVID-19 conspiracy theories

DR Grimes - PLoS One, 2021 - journals.plos.org
The coronavirus pandemic has seen a marked rise in medical disinformation across social
media. A variety of claims have garnered considerable traction, including the assertion that …

Modelling science trustworthiness under publish or perish pressure

DR Grimes, CT Bauch… - Royal Society open …, 2018 - royalsocietypublishing.org
Scientific publication is immensely important to the scientific endeavour. There is, however,
concern that rewarding scientists chiefly on publication creates a perverse incentive …

A mechanistic investigation of the oxygen fixation hypothesis and oxygen enhancement ratio

DR Grimes, M Partridge - Biomedical physics & engineering …, 2015 - iopscience.iop.org
The presence of oxygen in tumours has substantial impact on treatment outcome; relative to
anoxic regions, well-oxygenated cells respond better to radiotherapy by a factor 2.5–3. This …

[HTML][HTML] On the viability of conspiratorial beliefs

DR Grimes - PloS one, 2016 - journals.plos.org
Conspiratorial ideation is the tendency of individuals to believe that events and power
relations are secretly manipulated by certain clandestine groups and organisations. Many of …

Health disinformation & social media: The crucial role of information hygiene in mitigating conspiracy theory and infodemics

DR Grimes - EMBO reports, 2020 - embopress.org
The satirist Johnathan Swift once lamented that “falsehood flies, and truth comes limping
after it”. Penned three centuries ago, these words seem alarmingly prescient: The paradox of …

Oxygen consumption dynamics in steady-state tumour models

DR Grimes, AG Fletcher… - Royal Society open …, 2014 - royalsocietypublishing.org
Oxygen levels in cancerous tissue can have a significant effect on treatment response:
hypoxic tissue is both more radioresistant and more chemoresistant than well-oxygenated …