Context Theory and simulation suggest that randomized controlled trials (RCTs) stopped
early for benefit (truncated RCTs) systematically overestimate treatment effects for the …

Objective To investigate the association between treatment induced change in high density
lipoprotein cholesterol and total death, coronary heart disease death, and coronary heart …

Objective To investigate the credibility of authors' claims of subgroup effects using a
representative sample of recently published randomised controlled trials. Design Systematic …

The precautionary principle is, according to Wikipedia,“a strategy for approaching issues of
potential harm when extensive scientific knowledge on the matter is lacking.” The evidence …

Importance The discontinuation of randomized clinical trials (RCTs) raises ethical concerns
and often wastes scarce research resources. The epidemiology of discontinued RCTs …

Objective To assess the reporting, extent, and handling of loss to follow-up and its potential
impact on the estimates of the effect of treatment in randomised controlled trials. Design …

Pregnant women may be at higher risk of severe complications associated with the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical …

OBJECTIVE. A count of 3 neonatal morbidities (bronchopulmonary dysplasia, brain injury,
and severe retinopathy of prematurity) strongly predict the risk of death or neurosensory …

Importance Red blood cell transfusions are commonly administered to infants weighing less
than 1000 g at birth. Evidence-based transfusion thresholds have not been established …

Background Systemic glucocorticoids reduce the incidence of bronchopulmonary dysplasia
among extremely preterm infants, but they may compromise brain development. The effects …