Postoperative radiotherapy, which forms part of breastconserving therapy, may not need to
encompass the whole breast. Apart from the consumption of huge resources and patients' …

To explain a bimodal pattern of hazard of relapse among early stage breast cancer patients
identified in multiple databases, we proposed that late relapses result from steady stochastic …

A revolution is challenging the dogma that local treatment for all patients with breast cancer
treated with breast conservation therapy must include postoperative radiotherapy delivered …

Summary Background The TARGIT-A trial compared risk-adapted radiotherapy using single-
dose targeted intraoperative radiotherapy (TARGIT) versus fractionated external beam …

Background After breast-conserving surgery, 90% of local recurrences occur within the
index quadrant despite the presence of multicentric cancers elsewhere in the breast. Thus …

Purpose: After apparently successful excision of breast cancer, risk of local recurrence
remains high mainly in the area surrounding the original tumor, indicating that wound …

Objective To determine whether risk adapted intraoperative radiotherapy, delivered as a
single dose during lumpectomy, can effectively replace postoperative whole breast external …

Cancer development is a stepwise process through which normal somatic cells acquire
mutations which enable them to escape their normal function in the tissue and become self …

PURPOSE: We have previously shown that delivering targeted radiotherapy to the tumour
bed intraoperatively is feasible and desirable. In this study, we report on the feasibility …

Aim: We believe that conservative treatment of early breast cancer may not require
radiotherapy that encompasses the whole breast in all patients. We have developed a novel …