Respective prevalence of the different carpentier classes of mitral regurgitation: a stepping stone for future therapeutic research and development

E de Marchena, A Badiye, G Robalino… - Journal of cardiac …, 2011 - Wiley Online Library
Objectives: To determine the prevalence of mitral regurgitation (MR) in the US adult
population by classifying its mechanisms according to Carpentier's functional class …

[HTML][HTML] FinnGen provides genetic insights from a well-phenotyped isolated population

MI Kurki, J Karjalainen, P Palta, TP Sipilä… - Nature, 2023 - nature.com
Population isolates such as those in Finland benefit genetic research because deleterious
alleles are often concentrated on a small number of low-frequency variants (0.1%≤ minor …

Defining the role of common variation in the genomic and biological architecture of adult human height

AR Wood, T Esko, J Yang, S Vedantam, TH Pers… - Nature …, 2014 - nature.com
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-
wide significance that together explained one-fifth of the heritability for adult height. By …

FinnGen: Unique genetic insights from combining isolated population and national health register data

MI Kurki, J Karjalainen, P Palta, TP Sipilä… - MedRxiv, 2022 - medrxiv.org
Population isolates such as Finland provide benefits in genetic studies because the allelic
spectrum of damaging alleles in any gene is often concentrated on a small number of low …

The Lancet Commission to reduce the global burden of sudden cardiac death: a call for multidisciplinary action

E Marijon, K Narayanan, K Smith, S Barra, C Basso… - The Lancet, 2023 - thelancet.com
Despite major advancements in cardiovascular medicine, sudden cardiac death (SCD)
continues to be an enormous medical and societal challenge, claiming millions of lives …

Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders

M Den Hoed, M Eijgelsheim, T Esko, BJJM Brundel… - Nature …, 2013 - nature.com
Elevated resting heart rate is associated with greater risk of cardiovascular disease and
mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 …

[HTML][HTML] Genetic loci associated with heart rate variability and their effects on cardiac disease risk

IM Nolte, ML Munoz, V Tragante, AT Amare… - Nature …, 2017 - nature.com
Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with
greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide …

Prevalence and prognostic significance of fragmented QRS complex in middle-aged subjects with and without clinical or electrocardiographic evidence of cardiac …

HK Terho, JT Tikkanen, JM Junttila, O Anttonen… - The American Journal of …, 2014 - Elsevier
We wanted to evaluate the prevalence and prognostic value of the fragmented QRS (fQRS)
complex, defined as changes in QRS morphology with various RSR′-patterns in 12-lead …

Genetic risk factors associated with preeclampsia and hypertensive disorders of pregnancy

JS Tyrmi, T Kaartokallio, AI Lokki… - JAMA …, 2023 - jamanetwork.com
Importance A genetic contribution to preeclampsia susceptibility has been established but is
still incompletely understood. Objective To disentangle the underlying genetic architecture of …

Women with PCOS have an increased risk for cardiovascular disease regardless of diagnostic criteria—a prospective population-based cohort study

MM Ollila, RK Arffman, E Korhonen… - European Journal of …, 2023 - academic.oup.com
Objective Polycystic ovary syndrome (PCOS) is associated with many cardiovascular
disease (CVD) risk factors, such as obesity, type 2 diabetes mellitus and hypertension …