Respective prevalence of the different carpentier classes of mitral regurgitation: a stepping stone for future therapeutic research and development
E de Marchena, A Badiye, G Robalino… - Journal of cardiac …, 2011 - Wiley Online Library
Objectives: To determine the prevalence of mitral regurgitation (MR) in the US adult
population by classifying its mechanisms according to Carpentier's functional class …
population by classifying its mechanisms according to Carpentier's functional class …
[HTML][HTML] FinnGen provides genetic insights from a well-phenotyped isolated population
Population isolates such as those in Finland benefit genetic research because deleterious
alleles are often concentrated on a small number of low-frequency variants (0.1%≤ minor …
alleles are often concentrated on a small number of low-frequency variants (0.1%≤ minor …
Defining the role of common variation in the genomic and biological architecture of adult human height
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-
wide significance that together explained one-fifth of the heritability for adult height. By …
wide significance that together explained one-fifth of the heritability for adult height. By …
FinnGen: Unique genetic insights from combining isolated population and national health register data
Population isolates such as Finland provide benefits in genetic studies because the allelic
spectrum of damaging alleles in any gene is often concentrated on a small number of low …
spectrum of damaging alleles in any gene is often concentrated on a small number of low …
The Lancet Commission to reduce the global burden of sudden cardiac death: a call for multidisciplinary action
E Marijon, K Narayanan, K Smith, S Barra, C Basso… - The Lancet, 2023 - thelancet.com
Despite major advancements in cardiovascular medicine, sudden cardiac death (SCD)
continues to be an enormous medical and societal challenge, claiming millions of lives …
continues to be an enormous medical and societal challenge, claiming millions of lives …
Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders
M Den Hoed, M Eijgelsheim, T Esko, BJJM Brundel… - Nature …, 2013 - nature.com
Elevated resting heart rate is associated with greater risk of cardiovascular disease and
mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 …
mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 …
[HTML][HTML] Genetic loci associated with heart rate variability and their effects on cardiac disease risk
IM Nolte, ML Munoz, V Tragante, AT Amare… - Nature …, 2017 - nature.com
Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with
greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide …
greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide …
Prevalence and prognostic significance of fragmented QRS complex in middle-aged subjects with and without clinical or electrocardiographic evidence of cardiac …
HK Terho, JT Tikkanen, JM Junttila, O Anttonen… - The American Journal of …, 2014 - Elsevier
We wanted to evaluate the prevalence and prognostic value of the fragmented QRS (fQRS)
complex, defined as changes in QRS morphology with various RSR′-patterns in 12-lead …
complex, defined as changes in QRS morphology with various RSR′-patterns in 12-lead …
Genetic risk factors associated with preeclampsia and hypertensive disorders of pregnancy
JS Tyrmi, T Kaartokallio, AI Lokki… - JAMA …, 2023 - jamanetwork.com
Importance A genetic contribution to preeclampsia susceptibility has been established but is
still incompletely understood. Objective To disentangle the underlying genetic architecture of …
still incompletely understood. Objective To disentangle the underlying genetic architecture of …
Women with PCOS have an increased risk for cardiovascular disease regardless of diagnostic criteria—a prospective population-based cohort study
MM Ollila, RK Arffman, E Korhonen… - European Journal of …, 2023 - academic.oup.com
Objective Polycystic ovary syndrome (PCOS) is associated with many cardiovascular
disease (CVD) risk factors, such as obesity, type 2 diabetes mellitus and hypertension …
disease (CVD) risk factors, such as obesity, type 2 diabetes mellitus and hypertension …