Safety and efficacy of high-flow nasal cannula therapy in preterm infants: a meta-analysis

SJ Kotecha, R Adappa, N Gupta, WJ Watkins… - …, 2015 - publications.aap.org
BACKGROUND AND OBJECTIVE: High-flow therapy is the most recent, and popular, mode
of respiratory support in neonates. However, the evidence supporting its efficacy and safety …

Acute lung injury in preterm newborn infants: mechanisms and management

M Chakraborty, EP McGreal, S Kotecha - Paediatric respiratory reviews, 2010 - Elsevier
Respiratory morbidity and mortality remain common in preterm infants. The immature
preterm lung is especially prone to injury. This process often starts in-utero due to maternal …

Pulmonary surfactant in newborn infants and children

M Chakraborty, S Kotecha - Breathe, 2013 - Eur Respiratory Soc
Educational aims To understand the composition, secretory pathways and functions of
pulmonary surfactant. To review the clinical evidence regarding the use of surfactants in …

Effect of minimally invasive surfactant therapy vs sham treatment on death or bronchopulmonary dysplasia in preterm infants with respiratory distress syndrome: the …

PA Dargaville, COF Kamlin, F Orsini, X Wang… - Jama, 2021 - jamanetwork.com
Importance The benefits of surfactant administration via a thin catheter (minimally invasive
surfactant therapy [MIST]) in preterm infants with respiratory distress syndrome are …

Two-year outcomes after minimally invasive surfactant therapy in preterm infants: follow-up of the OPTIMIST-a randomized clinical trial

PA Dargaville, COF Kamlin, F Orsini, X Wang… - JAMA, 2023 - jamanetwork.com
Importance The long-term effects of surfactant administration via a thin catheter (minimally
invasive surfactant therapy [MIST]) in preterm infants with respiratory distress syndrome …

Role of pulmonary infection in the development of chronic lung disease of prematurity

ML Beeton, NC Maxwell, PL Davies… - European …, 2011 - Eur Respiratory Soc
We studied the role of ante-and post-natal infection in the development of chronic lung
disease (CLD) of prematurity. 192 newborn infants (61 term and 131 pre-term of< 34 weeks …

[HTML][HTML] Efficacy and safety of systemic hydrocortisone for the prevention of bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis

IP Morris, N Goel, M Chakraborty - European journal of pediatrics, 2019 - Springer
Early lung inflammation has been implicated in the pathogenesis of bronchopulmonary
dysplasia (BPD). We aimed to establish the efficacy and safety of systemic hydrocortisone …

[HTML][HTML] Non-invasive respiratory support in preterm infants

L Boel, T Hixson, L Brown, J Sage, S Kotecha… - Paediatric respiratory …, 2022 - Elsevier
Survival of preterm infants has increased steadily over recent decades, primarily due to
improved outcomes for those born before 28 weeks of gestation. However, this has not been …

Global health systems' data science approach for precision diagnosis of sepsis in early life

K Iregbu, A Dramowski, R Milton, E Nsutebu… - The Lancet Infectious …, 2022 - thelancet.com
Neonates and children in low-income and middle-income countries (LMICs) contribute to the
highest number of sepsis-associated deaths globally. Interventions to prevent sepsis …

[HTML][HTML] Challenging molecular dogmas in human sepsis using mathematical reasoning

P Ghazal, PRS Rodrigues, M Chakraborty… - …, 2022 - thelancet.com
Sepsis is defined as a dysregulated host-response to infection, across all ages and
pathogens. What defines a dysregulated state remains intensively researched but …