User profiles for "author:Michael Rigby"

Michael Rigby

- Verified email at keele.ac.uk - Cited by 4570

Michael J. Rigby

- Verified email at mayo.edu - Cited by 498

Molecular and functional diversity of the expanding GABA‐A receptor gene family

PJ Whiting, TP Bonnert, RM McKernan… - Annals of the New …, 1999 - Wiley Online Library
Fast inhibitory neurotransmission in the mammalian CNS is mediated primarily by the
neurotransmitter γ‐aminobutyric acid (GABA), which, upon binding to its receptor, leads to …

[HTML][HTML] Artificial intelligence in clinical decision support: challenges for evaluating AI and practical implications

F Magrabi, E Ammenwerth, JB McNair… - Yearbook of medical …, 2019 - thieme-connect.com
Objectives: This paper draws attention to: i) key considerations for evaluating artificial
intelligence (AI) enabled clinical decision support; and ii) challenges and practical …

[HTML][HTML] Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-β precursor protein and amyloidogenic Aβ peptide formation

FG Gervais, D Xu, GS Robertson, JP Vaillancourt… - Cell, 1999 - cell.com
The amyloid-β precursor protein (APP) is directly and efficiently cleaved by caspases during
apoptosis, resulting in elevated amyloid-β (Aβ) peptide formation. The predominant site of …

[HTML][HTML] Functional role of adult hippocampal neurogenesis as a therapeutic strategy for mental disorders

H Jun, S Mohammed Qasim Hussaini, MJ Rigby… - Neural …, 2012 - hindawi.com
Adult neurogenesis, the process of generating new neurons from neural stem cells, plays
significant roles in synaptic plasticity, memory, and mood regulation. In the mammalian …

[BOOK][B] Paediatric cardiology

RH Anderson, EJ Baker, A Redington, ML Rigby… - 2009 - books.google.com
As patients live longer and need to be treated over the long term and the management of
pediatric cardiology problems and congenital heart disease moves more into the …

[HTML][HTML] Characterization of a novel sphingosine 1-phosphate receptor, Edg-8

DS Im, CE Heise, N Ancellin, BF O'Dowd, G Shei… - Journal of Biological …, 2000 - ASBMB
Three G protein-coupled receptors (Edg-1, Edg-3, and Edg-5) for the lysolipid phosphoric
acid mediator sphingosine 1-phosphate have been described by molecular cloning. Using a …

Visions and strategies to improve evaluation of health information systems: Reflections and lessons based on the HIS-EVAL workshop in Innsbruck

E Ammenwerth, J Brender, P Nykänen… - International journal of …, 2004 - Elsevier
Background: Health care is entering the Information Society. It is evident that the use of
modern information and communication technology offers tremendous opportunities to …

Total anomalous pulmonary venous connection: morphology and outcome from an international population-based study

AN Seale, H Uemura, SA Webber, J Partridge… - Circulation, 2010 - Am Heart Assoc
Background—Late mortality after repair of total anomalous pulmonary venous connection is
frequently associated with pulmonary venous obstruction (PVO). We aimed to describe the …

θ, a novel γ-aminobutyric acid type A receptor subunit

TP Bonnert, RM McKernan, S Farrar… - Proceedings of the …, 1999 - National Acad Sciences
γ-Aminobutyric acid type A (GABA-A) receptors are a major mediator of inhibitory
neurotransmission in the mammalian central nervous system, and the site of action of a …

STARE-HI—Statement on reporting of evaluation studies in Health Informatics

J Talmon, E Ammenwerth, J Brender… - International journal of …, 2009 - Elsevier
OBJECTIVE: Development of guidelines for publication of evaluation studies of Health
Informatics applications. METHODS: An initial list of issues to be addressed in reports on …