OBJECTIVE Several studies have suggested an association between specific diabetes
treatment and cancer mortality. We studied the association between metformin use and …

Context Chronic kidney disease (CKD) is prevalent in older individuals, but the risk
implications of low estimated glomerular filtration rate (eGFR) and high albuminuria across …

Objective and Design Gliclazide has been associated with a low risk of hypoglycemic
episodes and beneficial long-term cardiovascular safety in observational cohorts. The aim of …

Using genome-wide association, we identify common variants at 2p12–p13, 6q26, 17q23
and 19q13 associated with serum creatinine, a marker of kidney function (P= 10− 10 to 10 …

OBJECTIVE—Skin autofluorescence is a noninvasive measure of the level of tissue
accumulation of advanced glycation end products, representing cumulative glycemic and …

Progressive CKD is generally detected at a late stage by a sustained decline in eGFR and/or
the presence of significant albuminuria. With the aim of early and improved risk stratification …

Background Change in albuminuria as a surrogate endpoint for progression of chronic
kidney disease is strongly supported by biological plausibility, but empirical evidence to …

Type 2 diabetes mellitus (T2DM) is associated with a higher risk of cancer and cancer-
related mortality. Increased blood glucose and insulin levels in T2DM patients may be, at …

OBJECTIVE—Chromium treatment has been reported to improve glycemic control and
insulin sensitivity in specific populations of patients with type 2 diabetes. The aim of this …

Background Self-monitoring of blood glucose (SMBG), including self-regulation, is an
important tool to achieve good glycemic control. However, many patients measure their …