Biomarkers and outcomes of COVID-19 hospitalisations: systematic review and meta-analysis
Objective To evaluate association between biomarkers and outcomes in COVID-19
hospitalised patients. COVID-19 pandemic has been a challenge. Biomarkers have always …
hospitalised patients. COVID-19 pandemic has been a challenge. Biomarkers have always …
[HTML][HTML] Kidney disease and COVID-19 disease severity—systematic review and meta-analysis
We aimed to identify prevalence and association of comorbid chronic kidney disease (CKD),
acute kidney injury (AKI) and utilization prevalence of continuous renal replacement therapy …
acute kidney injury (AKI) and utilization prevalence of continuous renal replacement therapy …
Hospitalizations due to preventable adverse reactions—a systematic review
NS Patel, TK Patel, PB Patel, VN Naik… - European journal of …, 2017 - Springer
Purpose The study aimed to measure the percentage of preventable adverse drug reactions
that lead to the hospitalization (PADR Ad) and to explore the heterogeneity in its estimation …
that lead to the hospitalization (PADR Ad) and to explore the heterogeneity in its estimation …
[HTML][HTML] Phase I/II study of the LAG-3 inhibitor ieramilimab (LAG525)±anti-PD-1 spartalizumab (PDR001) in patients with advanced malignancies
Background Lymphocyte-activation gene 3 (LAG-3) is an inhibitory immunoreceptor that
negatively regulates T-cell activation. This paper presents preclinical characterization of the …
negatively regulates T-cell activation. This paper presents preclinical characterization of the …
Decay of SARS-CoV-2 RNA along the wastewater treatment outfitted with Upflow Anaerobic Sludge Blanket (UASB) system evaluated through two sample …
For the first time, we present, i) an account of decay in the genetic material loading of SARS-
CoV-2 during Upflow Anaerobic Sludge Blanket (UASB) treatment of wastewater, and ii) …
CoV-2 during Upflow Anaerobic Sludge Blanket (UASB) treatment of wastewater, and ii) …
[PDF][PDF] Oligoadenylate-synthetase-family protein OASL inhibits activity of the DNA sensor cGAS during DNA virus infection to limit interferon production
Interferon-inducible human oligoadenylate synthetase-like (OASL) and its mouse ortholog,
Oasl2, enhance RNA-sensor RIG-I-mediated type I interferon (IFN) induction and inhibit …
Oasl2, enhance RNA-sensor RIG-I-mediated type I interferon (IFN) induction and inhibit …
[PDF][PDF] Kinetic analysis of Cas12a and Cas13a RNA-Guided nucleases for development of improved CRISPR-Based diagnostics
EA Nalefski, N Patel, PJY Leung, Z Islam, RM Kooistra… - Iscience, 2021 - cell.com
Bacterial CRISPR systems provide acquired immunity against invading nucleic acids by
activating RNA-programmable RNases and DNases. Cas13a and Cas12a enzymes bound …
activating RNA-programmable RNases and DNases. Cas13a and Cas12a enzymes bound …
Structural basis for HCMV Pentamer receptor recognition and antibody neutralization
Human cytomegalovirus (HCMV) represents the viral leading cause of congenital birth
defects and uses the gH/gL/UL128-130-131A complex (Pentamer) to enter different cell …
defects and uses the gH/gL/UL128-130-131A complex (Pentamer) to enter different cell …
[PDF][PDF] Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry
M Kschonsak, L Rougé, CP Arthur, H Hoangdung… - Cell, 2021 - cell.com
Human cytomegalovirus (HCMV) infects the majority of the human population and
represents the leading viral cause of congenital birth defects. HCMV utilizes the …
represents the leading viral cause of congenital birth defects. HCMV utilizes the …
Structural architecture of the human NALCN channelosome
Depolarizing sodium (Na+) leak currents carried by the NALCN channel regulate the resting
membrane potential of many neurons to modulate respiration, circadian rhythm, locomotion …
membrane potential of many neurons to modulate respiration, circadian rhythm, locomotion …