User profiles for "author:Vidu Garg"

Vidu Garg

Director, Center for Cardiovascular Research, Nationwide Children's Hospital
Verified email at nationwidechildrens.org
Cited by 9200

Genetic basis for congenital heart disease: revisited: a scientific statement from the American Heart Association

ME Pierpont, M Brueckner, WK Chung, V Garg… - Circulation, 2018 - Am Heart Assoc
This review provides an updated summary of the state of our knowledge of the genetic
contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial …

Mutations in NOTCH1 cause aortic valve disease

V Garg, AN Muth, JF Ransom, MK Schluterman… - Nature, 2005 - nature.com
Calcification of the aortic valve is the third leading cause of heart disease in adults. The
incidence increases with age, and it is often associated with a bicuspid aortic valve present …

Molecular genetics of aortic valve disease

V Garg - Current opinion in cardiology, 2006 - journals.lww.com
The recent genetic and biochemical findings provide novel insights into the molecular and
genetic basis for aortic valve dysmorphogenesis and calcification. Future studies focusing …

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5

V Garg, IS Kathiriya, R Barnes, MK Schluterman… - Nature, 2003 - nature.com
Congenital heart defects (CHDs) are the most common developmental anomaly and are the
leading non-infectious cause of mortality in newborns. Only one causative gene, NKX2-5 …

Maternal hyperglycemia and fetal cardiac development: Clinical impact and underlying mechanisms

M Basu, V Garg - Birth defects research, 2018 - Wiley Online Library
Congenital heart disease (CHD) is the most common type of birth defect and is both a
significant pediatric and adult health problem, in light of a growing population of survivors …

Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development

V Garg, C Yamagishi, T Hu, IS Kathiriya… - Developmental …, 2001 - Elsevier
Appropriate interactions between the epithelium and adjacent neural crest-derived
mesenchyme are necessary for normal pharyngeal arch development. Disruption of …

Spectrum of heart disease associated with murine and human GATA4 mutation

SK Rajagopal, Q Ma, D Obler, J Shen… - Journal of molecular and …, 2007 - Elsevier
The transcription factor GATA4 is essential for heart morphogenesis. Heterozygous mutation
of GATA4 causes familial septal defects. However, the phenotypic spectrum of heterozygous …

Genetics of congenital heart disease

AA Richards, V Garg - Current cardiology reviews, 2010 - ingentaconnect.com
Cardiovascular malformations are the most common type of birth defect and result in
significant mortality worldwide. The etiology for the majority of these anomalies remains …

[HTML][HTML] Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development

M Maitra, MK Schluterman, HA Nichols… - Developmental …, 2009 - Elsevier
Congenital heart disease is the most common type of birth defect with an incidence of 1%.
Previously, we described a point mutation in GATA4 that segregated with cardiac defects in …

A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects

H Yamagishi, V Garg, R Matsuoka, T Thomas… - Science, 1999 - science.org
Microdeletions of chromosome 22q11 are the most common genetic defects associated with
cardiac and craniofacial anomalies in humans. A screen for mouse genes dependent on …