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Systematic review and meta-analysis
Tranexamic acid reduces surgical bleeding: Does one size fit all?
  1. Raviraj Raveendran,
  2. Jean Wong
  1. Department of Anesthesia, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
  1. Correspondence to: Dr Jean Wong, Department of Anesthesia, Toronto Western Hospital University of Toronto, 399 Bathurst Street, 2MC-434, Toronto, Ontario, Canada M5T 2S8; jean.wong{at}uhn.ca

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Context

Tranexamic acid (TXA) reduces the need for blood transfusion in surgery. However, the extent of blood loss reduction associated with TXA when used for different types of surgery is still unclear. Furthermore, there is a lack of consensus regarding the dosing and timing of TXA administration, with previous studies reporting highly variable dosage and timing of administration.1 Ker and colleagues attempt to address these issues.

Methods

This study uses the same literature search the authors used in a previous systematic review of the effects of TXA on transfusion requirement.2 A total of 8030 patients from 104 randomised …

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