THERAPEUTICS

Aimonino Ricauda N, Tibaldi V, Leff B, et al. Substitutive "hospital at home" versus inpatient care for elderly patients with exacerbations of chronic obstructive pulmonary disease: a prospective randomized, controlled trial. J Am Geriatr Soc 2008;56:493–500.

GP/FP/Primary care 6/7; Internal medicine 6/7; Geriatrics 5/7; Respirology 5/7; Emergency medicine 5/7

Cumming RG, Sherrington C, Lord SR, et al. Cluster randomised trial of a targeted multifactorial intervention to prevent falls among older people in hospital. BMJ 2008;336:758–60.

Internal medicine 6/7; Geriatrics 6/7

James MT, Conley J, Tonelli M, et al. Meta-analysis: antibiotics for prophylaxis against hemodialysis catheter-related infections. Ann Intern Med 2008;148:596–605.

Infectious disease 5/7; Nephrology 6/7

Kastelein JJ, Akdim F, Stroes ES, et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med 2008;358:1431–43.

GP/FP/Primary care 6/7; Cardiology 6/7; Endocrine 6/7

Koizumi W, Narahara H, Hara T, et al. S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial. Lancet Oncol 2008;9:215–21.

Oncology 6/7; Oncology/Gastrointestinal 7/7

Kramer MS, Fombonne E, Igumnov S, et al. Effects of prolonged and exclusive breastfeeding on child behavior and maternal adjustment: evidence from a large, randomized trial. Pediatrics 2008;121:e435–40.

GP/FP/Obstetrics 6/7; Obstetrics 6/7; Paediatrics 6/7

Lopez LM, Grimes DA, Gallo MF, et al. Skin patch and vaginal ring versus combined oral contraceptives for contraception. Cochrane Database Syst Rev 2008;(1):CD003552.

Gynaecology 6/7; Obstetrics 6/7

Marti-Carvajal A, Salanti G, Cardona AF. Human recombinant activated protein C for severe sepsis. Cochrane Database Syst Rev 2008;(1):CD004388.

Internal medicine 6/7; Infectious disease 6/7; Intensivist …