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Therapeutics
Review: Antibiotic prophylaxis reduces infectious complications in caesarean delivery

https://doi.org/10.1136/ebm.4.6.179

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    Smaill F, Hofmeyr GJ. Antibiotic prophylaxis for Cesarean section. Cochrane Review, latest version 25 Feb 1999. In: The Cochrane Library. Oxford: Update Software.

    Question

    In women having caesarean delivery (c-section), does antibiotic prophylaxis reduce the incidence of endometritis, fever, wound infection, urinary tract infection (UTI), or other serious infection?

    Data sources

    Studies were identified by using the specialised register of controlled trials for the Cochrane Pregnancy and Childbirth review group.

    Study selection

    Studies were selected if they were randomised controlled trials that compared any prophylactic antibiotic regimen with placebo or no treatment for c-section.

    Data extraction

    Data were extracted on setting, antibiotic regimen, and methodological quality. Main outcomes were endometritis; fever; wound infection; UTI; and other serious infection (bacteraemia, septic shock, septic thrombophlebitis, nec-rotising fasciitis, or death from in-fection).

    Main results

    66 trials (9365 patients) were included. No significant heterogeneity existed among the trials. When all trials of c-section were combined, antibiotic prophylaxis reduced …

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