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Review: anticholinergics in addition to β2 agonists improve outcome in children and adults with acute asthma

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 Q In children and adults with acute asthma exacerbations, do inhaled anticholinergic agents plus β2 agonists improve outcome more than β2 agonists alone?

Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Internal medicine ★★★★★★☆ Emergency medicine ★★★★★★☆ Allergy & immunology ★★★★★★☆ Respirology ★★★★★☆☆ Paediatrics ★★★★★★☆

METHODS

Embedded ImageData sources:

Medline, EMBASE/Excerpta Medica, CINAHL, and the Cochrane Controlled Trials Register (to April 2005); hand searches of the reference lists of relevant articles and the top 20 respiratory journals; and the pharmaceutical company.

Embedded ImageStudy selection and assessment:

randomised controlled trials (RCTs), published as full articles in any language, that compared single or repeated doses of inhaled anticholinergic agents plus inhaled β2 agonists with inhaled β2 agonists alone for treatment of children (1.5–17 y of age) or adults (⩾18 y of age) with acute exacerbations …

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