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Review: azathioprine, infliximab, certolizumab, and adalimumab are effective for maintaining remission in Crohn’s disease

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A K Akobeng

Dr A K Akobeng, Booth Hall Children’s Hospital, Manchester, UK;


Which interventions are effective for maintaining remission in Crohn’s disease?


Included studies evaluated interventions for maintaining remission in Crohn’s disease. Outcome was maintenance of remission (or relapse).


Medline (1966 to May 2007), Cochrane Library (Issue 2, 2007), and Cochrane Inflammatory Bowel Disease Group were searched for randomised controlled trials (RCTs) or systematic reviews or meta-analyses of RCTs. 8 interventions (azathioprine, 5-aminosalicylates, corticosteroids, budesonide, antimycobacterial agents, probiotics, omega-3 fatty acids, and enteral nutrition) were evaluated in systematic reviews, and 6 interventions (methotrexate, infliximab, adalimumab, natalizumab, certolizumab, and ciclosporin) were evaluated in RCTs. …

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