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Weight loss in obese patients with asthma improved lung function and health status

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 QUESTION: In obese patients with asthma, does weight loss improve lung function and health status and alleviate symptoms?

Design

Randomised (allocation concealed*), unblinded,* controlled trial with 1 year follow up.

Setting

Outpatient clinic in Helsinki, Finland.

Patients

38 patients who were 18–60 years of age (mean age 49 y, 76% women), had a body mass index of 30 to 42, had asthma with a spontaneous diurnal variation or a bronchodilator response of ≥15%, and were non-smokers. Exclusion criteria were pregnancy; history of bulimia or anorexia; other severe disease, including heart, thyroid, liver, or gallbladder disorders; insulin or systemic steroid treatment; or history of food allergy or intolerance to any element of the intervention diet. Follow up was complete.

Intervention

Patients were allocated to a weight loss group (n=19) or …

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Footnotes

  • Sources of funding: Finnish Culture Foundation; Association of the Pulmonary Disabled; Wilhelm and Else Stockmann Foundation.

  • For correspondence: Dr B Stenius-Aarniala, Department of Medicine, University Central Hospital, PL 340 Helsinki, FIN-00029 HYKS, Finland.

  • * See glossary.