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Therapeutics
Review: antileukotrienes are less effective than inhaled corticosteroids in chronic asthma

https://doi.org/10.1136/ebm.8.2.49

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    (2002) Cochrane Database Syst Rev 3, CD002314. Ducharme FM, Hicks GC.. Anti-leukotriene agents compared to inhaled corticosteroids in the management of recurrent and/or chronic asthma in adults and children.. ;(. ):. (latest version 15 Jan 2002).

    
 
 QUESTION: In patients with chronic asthma, are daily antileukotrienes (ALs) as safe and effective as inhaled corticosteroids (ICSs)?

    Data sources

    Studies were identified by searching Medline (1966–2002), EMBASE/Excerpta Medica (1980–2002), CINAHL (1982–2002), the Cochrane Airways Group register of randomised controlled trials (RCTs), the Cochrane Controlled Trials Register (to January 2002); checking the reference lists of all relevant trials; contacting the pharmaceutical companies that manufacture ALs; and contacting colleagues and trialists in the field of paediatric asthma.

    Study selection

    Studies were selected if they were RCTs comparing daily oral ALs at usual licensed doses with any type of ICS in children ≥2 years of age and adults with chronic asthma. Interventions had to be administered for ≥30 days.

    Data extraction

    Data were extracted independently by 2 reviewers blinded to identifying information about …

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    Footnotes

    • For correspondence: Dr F Ducharme, Montreal Children’s Hospital, Montreal, Quebec, Canada.francine.ducharme{at}muhc.mcgill.ca

    • Abstract and commentary also appear in ACP Journal Club.

    • Source of funding: Fonds de la Santé du Québec Canada.