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Q In postmenopausal women with low bone mineral density (BMD) who had been receiving daily alendronate for a mean of 5 years, what is the effect of continuing alendronate treatment for 5 years compared with discontinuing it?
Clinical impact ratings GP/FP/Primary care ★★★★★★☆ Endocrine ★★★★★★☆ Rheumatology ★★★★★★☆ Internal medicine ★★★★★☆☆ Surgery—orthopaedics ★★★★★☆☆
randomised placebo controlled trial (Fracture Intervention Trial [FIT] Long-term Extension [FLEX]).
unclear allocation concealment.*
blinded (clinicians, participants, data collectors, and outcome assessors).*
Follow up period:
10 clinical centres in the US.
1099 postmenopausal women (mean age 73 y, 97% white) who had had low femoral neck BMD (<0.68 g/cm2) and had been allocated to alendronate (5 mg/d for 2 y and 10 …
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