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Review: multiple doses of antenatal corticosteroids prevent preterm neonatal respiratory disease more than a single dose

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Dr C Crowther

Correspondence to: Dr C Crowther, University of Adelaide, Adelaide, South Australia, Australia;


In women at risk of preterm birth, what is the effectiveness and safety of multiple doses of antenatal corticosteroids (ACSs) compared with a single dose for preventing neonatal respiratory disease?


Studies comparing repeat dose(s) of ACSs with placebo or no treatment for preventing neonatal morbidity in women still at risk of preterm delivery ⩾7 days after a first dose were selected. Outcomes were respiratory distress syndrome, severe lung disease, serious infant morbidity, birthweight, perinatal mortality, and maternal morbidity.


Cochrane Pregnancy and Childbirth Group’s trials register (February 2007); Cochrane Central Register of Controlled Trials, Medline, EMBASE/Excerpta Medica, and Current Contents (to November 2006); reference lists; and abstracts of major congresses were searched for randomised controlled trials (RCTs). Experts …

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  • Source of funding: Australian Department of Health and Aging.