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Dr S Yusuf, Hamilton Health Sciences, Hamilton, Ontario, Canada; email@example.com
randomised controlled trial (ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial [ONTARGET]).
blinded (patients, clinicians, and outcome assessors).*
733 centres in 40 countries.
25 620 patients ⩾55 years of age (mean age 66 y, 73% men) who had coronary or peripheral artery disease, cerebrovascular disease, or diabetes with end-organ damage. Exclusion criteria included intolerance to or inability to discontinue angiotensin-converting enzyme (ACE) inhibitors or angiotensin-receptor blockers (ARBs), and congestive heart failure (HF).
telmisartan, 80 mg/day (n = 8542); ramipril, 5 mg/day in the first 2 weeks, …
Source of funding: Boehringer Ingelheim; Heart and Stroke Foundation of Ontario; Canadian Institutes of Health Research.