Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Dr J Thomas, San Diego Hospice and Palliative Care, San Diego, CA, USA; firstname.lastname@example.org
randomised placebo controlled trial.
unclear allocation concealment.*
blinded (patients, healthcare providers, and outcome assessors).*
27 nursing homes, hospice sites, and palliative care centres in the USA and Canada.
133 patients ⩾18 years of age (median age 71 y, 57% women) who had terminal illness with life expectancy ⩾1 month, were receiving opioids for analgesia, and had opioid-induced constipation (<3 laxations in the previous wk or no laxation in the previous 48 h, despite having taken laxatives for ⩾3 d).
subcutaneous methylnaltrexone, 0.15 mg/kg body weight (n = 62), or placebo (n = 71) every other day for 2 weeks. Laxatives could be taken as needed but not within 4 hours of the study drug. …
Source of funding: Progenics Pharmaceuticals.