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Decision analysis
Population benefits of HPV vaccination for boys: a complex equation
  1. David Gabriel Regan
  1. Kirby Institute, University of New South Wales, Coogee, Australia
  1. Correspondence to David Gabriel Regan
    Kirby Institute, University of New South Wales, 45 Beach Street, Coogee, NSW 2034, Australia; dregan{at}

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With the licensing and subsequent roll-out of female vaccination against human papillomavirus (HPV) in many, mainly high-resource settings, there has emerged a chorus of voices advocating vaccination for males. The interest in male vaccination has intensified with the publication of early observational data from Australia heralding the effectiveness of vaccination when high coverage is achieved1 ,2 and the results of clinical trials demonstrating efficacy against infection and disease in males.3 A recent mathematical modelling study by Brisson et al provides estimates of the potential long-term benefits of HPV vaccination, including the incremental benefit of adding male vaccination to an existing female-only programme.


A previously described4 individual-based transmission-dynamic model was developed and calibrated to sexual behaviour and HPV …

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  • Competing interests DR is the recipient of an Australian Research Council Linkage Project (grant number LP0883831). CSL Ltd is a Partner Organisation on this project. Dr Regan has received honoraria from CSL Ltd.

  • Note Note Since this commentary was written, the Pharmaceutical Benefits Advisory Committee (PBAC) has recommended that males be included in the government funded National HPV Immunisation Program in Australia