You are here

Article Text

Article menu
Download PDFPDF
Therapeutics/Prevention
Randomised controlled trial
The RTS,S/AS01 vaccine continues to show modest protection against malaria in African infants and children
  1. Philip J Rosenthal
  1. Department of Medicine, University of California, San Francisco, California, USA
  1. Correspondence to : Dr Philip J Rosenthal, Department of Medicine, University of California, San Francisco, CA 94143, USA; philip.rosenthal{at}ucsf.edu

https://doi.org/10.1136/ebmed-2015-110231

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Commentary on: RTS,S Clinical Trials Partnership. Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. Lancet 2015;386:31–45.OpenUrlCrossRefPubMed

    Context

    Malaria remains one of the greatest infectious burdens in the world.1 The RTS,S vaccine results from decades of research showing that human responses to the Plasmodium falciparum circumsporozoite protein can protect against malaria.2 Vaccine developments benefitted from adjuvant optimisation, with AS01 chosen for recent trials. RTS,S has been extensively studied in African children recently, with vaccine efficacy approximately 25–50% against both symptomatic and severe malaria, but efficacy lower in infants than in children and waning over time after immunisation.3–5 This report provides final follow-up data for a large phase III trial conducted at 11 sites in sub-Saharan Africa. It offers new insights into the long-term efficacy of …

    View Full Text

    Footnotes

    • Competing interests None declared.

    • Provenance and peer review Commissioned; internally peer reviewed.